Booth Id:
CHEM068I
Category:
Energy: Sustainable Materials and Design
Year:
2015
Finalist Names:
Agababyan, Daniil
Abstract:
The copper(l)-catalyzed azide-alkyne cycloaddition(CuAAC) is one of the premier example of click chemistry, a term which means a set of 'almost perfect' bond-forming reactions useful for rapid assembly of molecules with desired function. In order to accelerate cycloaddition reaction and prevent undesirable ones, different ligands are often used.
I suggested, that poly(oxyminoalkyl)amines could be good accelerating ligands.
For investigation of their catalytic activity, a range of poly(oxyminoalkyl)amines was tested as accelerating ligands in CuAAC. Most of them have shown high performance and the best results were obtained with specially synthesized ligand which contained bis(beta-oximinoalkyl)amine fragment connected to 1,2,3-triazole ring. Its activity approximately 10 times surpassed the most used in CuAAC ligand TBTA [Tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine]. Its high catalytic activity was proved on various azide and acetylenes. According to these results, I may claim that the new high-efficient ligand will find applications in clickchemistry, in particular in bioconjugation and organic synthesis.
Awards Won:
Fourth Award of $500