Booth Id:
TMED020
Category:
Translational Medical Science
Year:
2021
Finalist Names:
Shi, Sophia (School: Dougherty Valley High School)
Abstract:
Acute kidney injury (AKI) is the sudden onset of kidney damage in which the kidneys cannot filter waste from the blood, requiring emergency hospitalization. AKI patient mortality rate is high in the ICU and is virtually impossible for doctors to predict because it is so unexpected. Currently, there is no hybrid model predicting AKI that takes advantage of two types of data. I collected de-identified patient data from the MIMIC-III database and de-identified kidney images and corresponding patient records from the Beijing Hospital of the Ministry of Health. Using data features including serum creatinine among others, I built a numeric model using MIMIC and Beijing Hospital data, and with the hospital ultrasounds, I built an image-only model. I used convolutional neural networks (CNN), VGG and Resnet for numeric data and Resnet for image data, and combined them into a hybrid model by concatenating feature maps of both types of models to create a new input. This input enters another CNN block and then two fully connected layers, ending in a binary output after running through Softmax and additional code. The hybrid model successfully predicted AKI and the highest AUROC of the model was 0.953, achieving an accuracy of 90% and F1-score of 0.91. This model can be implemented into urgent clinical settings such as the ICU and aid doctors by assessing the risk of AKI shortly after the patient’s admission to the ICU, so that doctors can take preventative measures and diminish mortality risks and severe kidney damage.