Booth Id:
CBIO074
Category:
Computational Biology and Bioinformatics
Year:
2021
Finalist Names:
Liang, Laurence (School: Marianopolis College)
Abstract:
My project aims to identify a therapy to treat COVID-19 infections using gene expression and a computer-assisted approach. My computer program, AMiF (Augmented miRNA Filtration Model) works to identify endogenous human miRNA sequences that could bind and inhibit SARS-Cov-2 replication, through a phenomenon called RNA interference. To achieve this objective, my computer program feeds an existing tool, miRDB, the SARS-Cov-2 genome, and then independently filters results through analyzing conserved regions and by browsing existing scholarly literature. As a result, my program identified a shortlist of human miRNA sequences, notably mIR-302c, which could be further experimented and tested as a therapy against COVID-19.
Awards Won:
Fourth Award of $500