Booth Id:
CHEM066
Category:
Chemistry
Year:
2018
Finalist Names:
Pham, Amy (School: Oak Grove High School)
Abstract:
According to the World Health Organization, approximately 40 million people worldwide are infected with HIV-1. While there is no cure for HIV-1, Highly Active Antiretroviral Therapy (HAART) is currently the only method of treatment that manages the infection giving the patient an improved quality of life and a longer lifespan. As viral resistance increases existing medications lose efficacy therefore there is a continual need for the development of new prescription drugs. Currently, the lab is investigating chemical synthesis strategies of novel quinolines to be tested against the HIV-integrase enzyme. Starting from commercially available substituted anthranilic acids, the researchers have prepared a series of multi-substituted quinolines over a nine steps linear synthesis. These compounds have been assayed for inhibition against HIV integrase and multimerization in Professor Jacques Kessl’s laboratory.